ESHIᴹᵀ Educational Webinars 2018

ESHIᴹᵀ Educational Webinars 2018

 

In a series of online lectures, distinguished experts in the field of hybrid imaging will share their knowledge about various modalities and subspecialties related to the fusion of nuclear medicine and radiology as well as molecular and translational imaging.

 

Moreover, the lectures will be uploaded to the MyUserArea, so every active member can enjoy and rewatch the lectures at their own convenience.

 

Please note: The first 5 lectures will be free to join for everybody whereas the last 5 will only be accessible for members of the society.

 

View the full schedule here
Eurosafe Imaging, IAEA and ESHIMT Webinar

CLINICAL HYBRID IMAGING: RADIATION ISSUES

Date: December 10, 2018
Time: 15:00 CET
Speakers: Ivo Rausch, Katrine Riklund
Registration: Click here!

This webinar on Clinical Hybrid Imaging: Radiation Issues is organised by EuroSafe Imaging together with the IAEA Radiation Protection of Patients (RPOP) Unit and the European Society for Hybrid, Molecular and Translational Imaging (ESHIMT).

Description and learning objectives

About the webinar:

Nuclear medicine imaging techniques and hybrid imaging devices (like SPECT/CT and PET/CT) are key elements of medical imaging today. The combination of a nuclear medicine imaging technique and an anatomical imaging modality, in particular, has been demonstrated to provide clinical value in patients with a range of benign and malignant diseases.

Imaging techniques like CT and nuclear medicine methods are based on the use of ionising radiation. In the case of CT, a X-ray transmission source rotates around the patient while a detector array on the opposite site of the patient acquires the range of photons transmitted through the body of the patient. In nuclear medicine examinations, patients are injected with a given amount of a radiotracer, a biomolecule labeled with a radioactive isotope, specific to the purpose of the functional, nuclear medicine examination. The emitted radiation from inside the patient can be measured, and from this data, the tracer distribution can be reconstructed.

In both, CT and nuclear medicine examinations, radiation energy is deposited in the body of the patients by the fractions of photons absorbed within the body tissues and by scattered photons. In combined imaging, patient exposure results from the added contributions from both CT and nuclear medicine examination.

Exposure to ionising radiation in a quantity as used in medical imaging bears the risk of stochastic effects like radiation induced cancer. Thus, these risks need to be taken into account when performing an examination and the rational for a radiation exposure should be based on the ALARA (as low as reasonably achievable) principle.

 

Learning objectives:

  • To understand where the dose is coming from in hybrid imaging examinations.
  • To understand the difference between different dose measures.
  • To understand the meaning of “risk” associated with radiation exposure from hybrid imaging.

 

About the speakers:

Ivo Rausch, PhD, studied Technical Physics at the University of Technology Vienna with a focus on radiation protection and nuclear physics and graduated in 2011. He joined the Division of Nuclear Medicine, Medical University of Vienna as a scientific employee in 2013.  Thereafter, I. Rausch joined the Center for Medical Physics and Biomedical Engineering (CMPBMT), where he also accomplished the PhD program in Medical Physics. Further, he completed the university course “Medical Physics”, which is compliant with the EFOMP and EU guidelines for the education of medical physics experts.

Today, he is a post doc researcher in the Quantitative Imaging and Medical Physics group at the CMPBMT. His interests relate to quantitative hybrid imaging in nuclear medicine with a special focus on PET/MRI and PET/CT. In close collaboration with the Division of Nuclear Medicine, he is engaged in several (clinical) studies and educational activities. He is a member of the working group “Medical Physics and Radiation Protection” of the Austrian Society of Nuclear Medicine and Molecular Imaging (OGNMB), member of the ESHIMT research committee and board member of the Austrian Society of Radiation Protection in Medicine (VSMÖ).

Katrine Riklund is full professor, consultant in diagnostic radiology and pro-vice-chancellor of Umeå University. Prior to her current positions, she headed both the Clinical Department of Radiology and Nuclear Medicine at Umeå University Hospital and served as deputy dean of the medical faculty between 2008 and 2011. She graduated at Umeå University in 1988, and licensed in radiology and nuclear medicine in 1994 and 1997, respectively. Prof. Riklund started her work in translational research between immunology and nuclear medicine by developing and evaluating monoclonal antibodies in the diagnosis and treatment of gynaecological cancers. She soon became interested in hybrid imaging, particularly to carry out research in cognition, neurodegeneration and movement disorders. She also works in prostate and colorectal cancer imaging research. She has served in many leadership roles for the European Society of Radiology (ESR) since 2009, and is the past-president of the European Society for Hybrid, Molecular and Translational Imaging (ESHIMT). She was the president of the Swedish Society of Radiology and the Swedish Society of Nuclear Medicine. She is also chairperson of the Centre for Medical Image Science and Visualisation at Linköping University, the Centre for Functional Brain Imaging and Wallenberg Centre for Molecular Medicine as well as for the Umeå Centre for Functional Brain Imaging at Umeå University, Sweden.


Webinar 10

PSMA-PET-MRI FOR DIAGNOSIS OF PROSTATE CANCER

Date: December 19, 2018
Time: 17:00 (CET)
Speakers: Assoc.-Prof. Dr. Pascal Baltzer (Vienna, Austria
Registration: Click here!

 

Webinario especial en español

ESTADIFICACIÓN TUMORAL CON PET/RM

Fecha: 16 de enero de 2018
Hora: 17:00 (CET)
Conferenciante: Dr. José Ramón García Garzón (Barcelona, España)
Registro: Haga clic aquí!


PAST WEBINARS 2018

 

 

Webinar 1 - CONCEPTS FOR TRANSLATIONAL RESEARCH IN ONCOLOGICAL IMAGING

Date: January 31, 2018
Time: 17:00 (CET)
Speaker: Prof. Dr. Konstantin Nikolaou (Tübingen, Germany)

 

Description:

In the era of functional and molecular imaging, delivering information beyond morphology, size and simple metrics, multiparametric
and multimodality imaging becomes ever more important. Also, in times of ever more complex therapies, e.g., applying molecular and immuno-therapies in many oncological entities, the need for standardized, reproducible, robust and (semi-)quantitative imaging biomarkers to assess or even predict therapy response is huge. The develpment of such biomarkers is only feasible if the underlying pathophysiology, e.g. of a tumor responding and reacting to therapy, is understood and if (surrogate) imaging biomarkers are developed in a translational fashion, bringing new modalities and imaging features from “bench-to-bedside” in its truest sense.
In this webinar, examples, methods and systematic approaches for such translational research in the development of imaging biomarkers in oncology will be explained and discussed.

Learning Objectives:

– to explain methods and systematic approaches for translational research in the development of imaging biomarkers in oncology
– to discuss underlying pathophysiologies and the meaning of surrogate markers derived from multi-modality imaging
– to speculate on future developments in the field

About the speaker:

Pic_Konstantin NikolaouKonstantin Nikolaou is Chairman of the Department of Diagnostic and Interventional Radiology in the Department of Radiology at the Eberhard-Karl-University in Tübingen, Germany. Prof. Nikolaou received his MD from the Ludwig-Maximilians-University of Munich in the year 2000, where he also became an Assistant Professor at the Department of Clinical Radiology, University Hospitals Munich, after finalizing his PhD-thesis on the topic of modern cardiovascular computed tomography techniques in 2007.

After working as a section chief of CT/PET-CT and MRI at the same department, he became Vice Chair of the Department of Clinical Radiology at the Ludwig-Maximilian-University in Munich in April 2007.

He also is former president of the European Society of Molecular and Functional Imaging in Radiology (ESMOFIR) and treasurer for the European Society of Cardiac Imaging (ESCR), Member of the Research Committee of the European Society of Radiology (ESR) and Honorary Member of the Greek Society of Radiology.

Prof. Konstantin Nikolaou joined the Eberhard-Karl-University Tübingen in April 2014 as Chairman of the Department of Diagnostic and Interventional Radiology. His main fields of interest are multimodality and multi-parametric imaging modalities in oncology as well as non-invasive imaging of cardiovascular diseases.

Webinar 2 - HYBRID IMAGING IN BREAST TUMORS

Date: February 21, 2018
Time: 17:00 (CET)
Speaker: Katja Pinker-Domenig MD, PhD, EBBI(New York, USA)

Learning Objectives

1. To understand the principle of multimodality multiparametric functional imaging of breast tumours with MR/PET.
2. To identify the potential and challenges of multiparametric breast MR/PET using different quantitative functional parameters.
3. To realise the potential of novel tracers for personalised medicine.

Description

W2_caseCancer development is characterised by several biological capabilities or so-called hallmarks, which comprise sustaining proliferative signalling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. With medicine entering the genomic era, personalised approaches towards treatment, which require a deeper understanding of the hallmarks of cancer, are being explored and ultimately will be implemented in patient care. To match advanced therapeutic strategies in the era of personalised medicine, diagnostic tests must be equally multilayered and complex to identify the relevant underlying processes of cancer development and progression.

In this context, multiparametric magnetic resonance imaging (MRI) and positron emission tomography/MRI (PET/MRI), which, in addition to morphologic changes, can simultaneously assess a multitude of functional cancer-related processes, have emerged as exceptionally powerful, versatile, and precise imaging techniques. Multiparametric functional imaging of the breast aims to simultaneously quantify and visualise multiple functional processes at the cellular and molecular levels to further elucidate the development and progression of breast cancer and the response to treatment.

There is evidence that multiparametric functional imaging, using different MRI and PET parameters, provides detailed information about the hallmarks of cancer and, thus, improves the diagnostic accuracy and assessment of response to neoadjuvant therapy. Multiparametric functional MRI provides a variety of techniques to assess functional tumour characteristics such as diffusion-weighted imaging, dynamic contrast-enhanced imaging and multi-nuclei magnetic resonance spectroscopic imaging. PET/(MRI) detects and quantifies radiolabelled tracer substances, which allows the measurement of specific functional characteristics of breast cancer such as increased glucose uptake, tumour hypoxia or hormonal receptor expression. This talk aims to summarize the current and emerging applications of PET/MRI in breast tumours.

About the speaker:

Katja Pinker-Domenig, MD, PhD, EBBI

Dr. Pinker-Domenig is an Associate Attending at the Department of Radiology/ W2_katja-pinkerBreast Service at the Memorial Sloan-Kettering Cancer Center/ Weill Cornell Medical College, New York, USA, Associate Professor of Radiology at the Department of Biomedical Imaging and Image-guided Therapy/Division of Molecular and Gender Imaging at the Medical University of Vienna, Austria and Affiliated Faculty at the Department of Scientific Computing at Florida State University, Tallahassee, USA. She serves as an Executive Board Member of the European Society of Breast Imaging (EUSOBI), Deputy Editor of the “Journal of Magnetic Resonance Imaging” and is editorial board member in several journals such as of “Insights into Imaging”, “European Radiology”, “Breast Care” and “British Journal of Radiology/ Case Reports“.

She is an expert in translational and clinical breast and oncologic gender imaging. Her research interests focus on molecular breast and oncologic gender imaging with advanced multiparametric high-field/ultra-high-field MRI and PET/MRI and radiogenomics in breast cancer. She has received recognition in terms of international prizes including the EUSOBI Carla Boetes Young Investigator Award 2014. She has obtained several national and international research grants in molecular imaging in oncologic gender imaging and has published more than >100 peer-reviewed papers in oncologic imaging.

Webinar 3 - HYBRID IMAGING IN CARDIOVASCULAR DISEASE – WHAT DO THE GUIDELINES SAY?

Webinar 3

HYBRID IMAGING IN CARDIOVASCULAR DISEASE – WHAT DO THE GUIDELINES SAY?

Date: March 28, 2018
Speaker: Prof.Dr. Matthias Gutberlet (Leipzig, Germany)

Description:

Despite its great potential, hybrid cardiovascular imaging is still not as widely-used as it should be. According to some of the most common indications for imaging in cardiovascular medicine and its potential in a clinical scenario three major topics will be discussed in the Webinar:

I. Coronary Artery Disease and Heart Failure
II. Endocarditis, especially Prosthetic Valve Endocarditis (PVE)
III. Vascular / Myocardial Inflammatory Disease (i.e. myocarditis / sarcoidosis)

 

Learning Objectives:

  • To learn more about the potential and already existing indications for hybrid imaging in the cardiovascular system
  • To know the advantages and disadvantages of a hybrid system
  • To get knowledge of the technical principles of a PET/MR system

 

About the speaker:

Pic_Matthias GutberletProf. Dr. Matthias Gutberlet is Specialist in Radiology and Nuclear Medicine and currently is Head of the Department for Diagnostic and Interventional Radiology at the University Leipzig. He is also Past-President of the European Society of Cardiac Radiology (ESCR).

Clinical Work:
Beside diagnostic imaging and treatment of diseases of the cardiovascular system our department provides the radiological service for the Park-Klinikum Leipzig with a main focus on the muscoloskeletal system, gastroenterology and pulmology. We are part of a “Onkozert” certified “Darm- and Pankreaszentrum” since 2008. My multimodality experience in oncology startet at the Charité, Campus Virchow, including PET/CT reading and was continued as a reviewer for Parexcel-Berlin in 2005/2006. At the University Leipzig I am still involved in clinical and research Activities at the PET/MR-system.

Research:
I was mainly involved in research projects dealing with Doppler-ultrasound, contrast agents, MDCT and MRI of the cardiovascular system, using the techniques of dynamic CTA, Dual Energy, iterative reconstruction, coronary CTA, MR-angiography, MR-volumetry, MR flow-measurements and MR-perfusion in humans and animal models. I am one of the project leaders of the German Competence Network for Congenital Heart Disease since 2003.

Recent studies of our group were dealing with dose reduction in CT, imaging and post-processing before and after TAVI and EVAR, MR viability assessment in comparison to SPECT, PET, MRI at 3.0T and studies on the assessment of inflammation by MRI. Furthermore, we have gathered the first experiences in PET/MR and interventional MRI.

Webinar 4 - PET/MRI - BEST OF BOTH WORLDS

Webinar 4

PET/MRI – BEST OF BOTH WORLDS

Date: April 25, 2018
Time: 17:00 (CET)
Speaker: PD Dr. Lale Umutlu (Essen, Germany)

 

Description:

This webinar on „PET/MRI- the best of both worlds“ aims to introduce residents and hybrid imagers into the diagnostic potential, applications fields and future appliances of PET/MR imaging.

After its introduction into clinical imaging in 2010 PET/MRI has been the focus of innumerous international scientific and clinical imaging trials, demonstrating its excellent diagnostic value for various application fields. While inital trials focussed on the comparison and demonstration of its equivalent diagnostic competence compared to PET/CT, the current scientific focus has shifted towards multiparametric imaging and the assessment of noninvasive biomarkers based on morphologic, functional, and metabolic imaging.

 

Learning objectives:

  1. To become familiar with the role of hybrid imaging in clinical imaging.
  2. To become familiar with the role of PET/MRI and its application fields
  3. To understand hybrid imaging applications in relationship to disease presentations.

Case Study:

Case study - ABCFig. 1

Which statements are true? Figure 1 shows

  1. Chronic changes in a patient with Crohn´s disease.
  2. The superiority of MRI over PET for detection of acute inflammation.
  3. Acute inflammation at the splenic flexure of the colon.
  4. The impairment of PET diagnostics in patients with insufficient bowel cleansing.
  5. No acute inflammation.

Correct answer further down

 

About the speaker:

umutlu_PETMRT2018Associate Prof. PD Dr. Lale Umutlu is Vice Chair and Head of the Clinical MR-PET and Ultrahighfield research group at the Department of Diagnostic and Interventional Radiology and Neuroradiology of the University Hospital Essen, Germany. After receiving her habilitation (Venia legendi) on ultra-highfield whole-body MR imaging in 2013, her focus of scientific research interest has expanded by MR PET, with a main focus on oncology and malignancies of the female pelvis in particular. She has given > 150 scientific and invited educational presentations as well as published in highly-ranked academic journals. As a member of various societies including European Society of Radiology, she has also been involved in a large number of workshops organized by the ESMRMB, ESOR, ESR and EDIR.

 

 

The correct answer of the quiz is 3: “Acute inflammation at the splenic flexure of the colon.”

Webinar 5 - RADIOMICS IN ONCOLOGY: PRINCIPLES AND CHALLENGES


RADIOMICS IN ONCOLOGY: PRINCIPLES AND CHALLENGES

 

Date: May 30, 2018
Speaker: Prof. Dr. Laure Fournier (Paris, France)

 

Description

Radiomics is a new ‘data-driven’ approach for extracting large sets of complex descriptors from routine (or not) clinical images. Advanced methods of image processing are applied to images in order to extract a large number of descriptors, such as texture analysis from histograms, co-occurrence matrices, fractal analysis, etc…

This large set of data can be analysed using bio-informatics and bio-statistics methods defining imaging ‘profiles’ correlated to gene expression profiles, often called radiogenomics, or to outcomes, such as treatment response or survival. The further development of these new methods faces challenges regarding data generation and access.

 

Learning objectives:

  1. To learn about new methods of image analysis derived from ‘-omics’ methods.
  2. To understand processing of big data derived from images.
  3. To become familiar with new vocabulary such as Radiomics, radiogenomics, clusters, heat maps, etc.

 

 

 

About the speaker

Photo CV L Fournier 2013Laure Fournier works as an Associate Professor at the Hôpital Européen Georges Pompidou, in Paris, France. Her time is divided between clinical work, specialising in urological and gynaecological cancers, and imaging research in the Laboratoire de Recherche en Imagerie (INSERM U970).

She is pursuing work on techniques of functional computed tomography (CT) and magnetic resonance imaging (MRI) in patients, to extract quantitative parameters from images reflecting tumour physiology and biology.

Her main field of interest is defining response to therapy, in particular for targeted therapies which require development of new response criteria.

Webinar 6 - PITFALLS OF PET/CT IN HEAD AND NECK ONCOLOGY


PITFALLS OF PET/CT IN HEAD AND NECK ONCOLOGY

Date: June 27, 2018
Time: 17:00 (CEST)
Speaker: Prof. Dr. Minerva Becker (Geneva, Switzerland)

Description

Positron emission tomography-computed tomography (PET/CT) with fluorine-18-fluorodeoxy-D-glucose (FDG) is an invaluable tool in head and neck cancer imaging. However interpretation of FDG PET/CT studies may be challenging because of the complex head and neck anatomy, physiological variants mimicking pathology, as well as unusual patterns of high or low FDG uptake.

The purpose of this lecture is to discuss the key imaging features and interpretation pitfalls of FDG PET/CT of the head and neck and how to avoid them. The pathophysiological mechanisms leading to potentially false positive and false negative interpretations are briefly reviewed, as well as the complementary use of high-resolution contrast enhanced PET/CT and – whenever necessary – ultrasonography and magnetic resonance imaging (MRI) with diffusion weighted sequences.

 

Learning Objectives

  1. To understand key imaging features of physiological and non-physiological FDG uptake in head and neck PET/CT studies.
  2. To learn both how to avoid over-diagnosis of benign conditions as malignancy and how to avoid missing out on relevant pathology.
  3. To know when to use other imaging modalities as complementary tools in order to avoid misinterpretation of head and neck PET/CT studies.

 

Teaser Case

Teaser

About the speaker

Minerva BeckerMinerva Becker studied medicine at the University of Berne in Switzerland and specialized in Radiology at the Insel Hospital, University of Berne.

Early in her career, she specialized in head and neck radiology and many of her scientific publications focus on radiologic‐pathologic correlation, as well as on the performance of MRI, CT, PET CT and PET MRI in head and neck pathologies. She is the author of over 130 scientific publications and review articles and she is co-­‐editor of Valvassouri’s Head and Neck Imaging. Her h index is 31.

She has received over 30 international and national scientific awards and has obtained several research grants supported by the Swiss National Science Foundation.

Minerva Becker serves as a reviewer for 12 scientific journals and she equally serves as external expert in international and national juries for the attribution of PhD theses.

She is currently Associate Professor of Radiology and Head of the Imaging Unit of Head and Neck and Maxillofacial Radiology at the Geneva University Hospital.

She is an enthusiastic teacher with over 350 invited lectures at international and national meetings. As Chairman of the Education Committee of the European Society of Head and Neck Radiology (ESHNR), she is in charge the European training curriculum and diploma in head and neck radiology. She is Past President of the ESHNR.

Webinar 7 - PET/MRI IN ABDOMINAL ONCOLOGY


PET/MRI IN ABDOMINAL ONCOLOGY

Date: September 26, 2018
Time: 17:00 (CEST)
Speaker: Prof. Dr. Vicky Goh (London, UK)

 

Description

This lecture will explore the potential of PET/MRI for abdominal cancers focussing on where PET/MRI may provide additional information to PET/CT .

 

Learning Objectives

  1. To be aware of the imaging capability & challenges of integrated PET/MRI
  2. To be aware of the potential of PET/MRI for assessing abdominal cancers
  3. To be aware of the evidence to date for PET/MRI in abdominal cancers

 

About the speaker

Vicky GohProfessor Vicky Goh is Chair of Clinical Cancer Imaging and Consultant Radiologist at Guy’s and St Thomas’. Educated at Cheltenham Ladies’ College and Cambridge University, she is President of the European Society of Oncologic Imaging, Fellow of the European Society of Abdominal and Gastrointestinal Radiology, and Faculty member of the European School of Radiology. She is on the editorial board of Radiology and European Radiology. She is an active contributor to National/International practice guidelines and policy.

Her research focuses on multimodality functional imaging and biomarker development in cancer with a special interest in gastrointestinal, lung and renal cancers. She has >100 peer reviewed papers. She has been a principal and co-applicant on project and infrastructure grants totalling £22M in the last 3 years including being the Chief Investigator of a NIHR HTA funded multicentre study of imaging in colorectal cancer (PROSPeCT). She has given >50 national/international keynote lectures and has an international reputation for translating novel functional imaging techniques into clinical practice.

Webinar 8 - PET/MRI IN TUMOUR AND DEMENTIA IMAGING: A ROUTINE CLINICAL TOOL?


Webinar 8

PET/MRI IN TUMOUR AND DEMENTIA IMAGING: A ROUTINE CLINICAL TOOL? 

Date: October 31, 2018
Time: 17:00 (CET)
Speaker: Prof. Dr. Sotirios Bisdas (London, UK)

 

At the conclusion of this webinar, participants will be able to:

  1. To identify the key indications for PET/MRI in tumour and dementia imaging.
  2. To recognize the hallmark PET/MRI findings in brain tumours and dementia-related neurodegeneration.
  3. To differentiate between the true disease forms and their mimics.
  4. To judge the clinical value of PET/MRI in tumour and dementia routine imaging.

 

Prof. Bisdas’ teaser case: 

45-year-old male patient with right frontal GBM (first diagnosis 2/2014) undergoes chemoradiation and subsequently follow-up MRI in 5/2014 demonstrating an enhancing, centrally necrotic mass with extensive perifocal oedema. The patient experienced also clinical deterioration.

The reporting neuroradiologist and the multidisciplinary neuro-oncology team considered an early relapse as the most likely diagnosis (preliminary progressive disease according to the modified RANO critaria) and recommended close surveillance with PET/MRI for further assessment and imaging-guided patient management.

Foll0w-up PET/MRI with methionine and advanced MRI sequences was performed in 7/2014.

 

About the speaker

IMG_0138Professor Sotirios Bisdas is Consultant Neuroradiologist and MRI Lead in the Lysholm Department of Neuroradiology at the National Hospital for Neurology and Neurosurgery in London, Associate Professor in Neuroradiology at UCL, and Professor of Radiology at University of Tübingen, Germany.

He has completed a post-doctoral scholarship in Neuroradiology Research at the Medical University of South Carolina, USA and holds a MSc. degree in “Advanced Oncology” from University of Ulm, Germany. His fields of expertise include advanced and functional MRI, ultra-high field (7T and 9.4T) MRI, and PET/MRI in brain diseases (neurooncology, dementia, epilepsy) and in head and neck cancer.

He has followed clinical neuro-PET/MRI since its advent and his first publication in brain tumours has been more than 240 times cited. He is also Clinical Lead of the Neurooncology flagship programme at the UCL Institute of Healthcare Engineering. Widely published with more than 130 PubMed-indexed authorships, he is also Editor and Editorial Board Member of several leading journals in Radiology and Neuroradiology, member of the Executive Committee of the ESHNR, and the ESR Research Committee.

Webinar 9 - PETRUS: POSITRON EMISSION TOMOGRAPHY REGISTERED ULTRASOUND


Webinar 9

PETRUS: POSITRON EMISSION TOMOGRAPHY REGISTERED ULTRASOUND 

Date: November 21, 2018
Time: 17:00 (CET)
Speakers: Prof.Dr. Bertrand Tavitian (Paris, France) & Prof.Dr. Mickael Tanter (Paris, France)

 

Lecture Description

PET and ultrasound are an ideal combination for hybrid imaging: PET–CT is the most sensitive molecular imaging modality, but it has low spatial and temporal resolution. Ultrasound imaging, especially the recently introduced Ultrafast ultrasound imaging (UUI) technology based on ultrasonic holography, leverages frame rates of up to several thousand images per second to quantitatively map, at high resolution, hemodynamic, biomechanical, electrophysiological and structural parameters. Theoretically, one can expect exquisite sensitivity, quantification, whole body imaging and a relatively large portfolio of molecular imaging targets on one side, together with low cost, simplicity and unmatched resolution on the other side.

We have built PETRUS (PET Registered Ultrasound); a preclinical PET–CT–UUI triple-imaging modality that integrates the three imaging modalities in one device for simultaneous, fully co-registered imaging, enabling image fusion independent of motion without increasing acquisition times [1]. PETRUS was assembled from existing, commercially available devices using lightweight and portable UUI instrumentation for which dedicated, customized sequences were developed. We showed that full, markerless, rigid-body three-dimensional registration was accurately achieved by controlling the ultrasound probe with a six-degrees-of-freedom motorized micropositioner and that the presence of the ultrasound probe had a negligible impact on the quality of the PET volumes [2]. Remarkably, PETRUS provides multi-parametric information currently unobtainable with any other non-invasive imaging method. Here I will present pre-clinical oncology and cardiology applications of fused, simultaneously acquired volumes of PETRUS images that yield unprecedented information.

[1] Provost J, Garofalakis A, Sourdon J,  et al. Simultaneous Positron Emission Tomography and Ultrafast Ultrasound for Hybrid Molecular, Anatomical, and Functional Imaging. Nature Biomed Eng 2018;2(2):85-94.[2] Perez-Liva M, Viel T, Yoganathan T, et al. Performance evaluation of the PET component of a hybrid PET/CT-ultrafast ultrasound imaging instrument. Phys Med Biol. 2018 Sep
21;63(19):19NT01. doi: 10.1088/1361-6560/aad946. PubMed PMID: 30091723.

 

 

Learning objectives

  1. Complementarity between PET and Ultrafast ultrasound imaging (UUI) for simultaneous preclinical imaging
  2. Characteristics of hybrid PET-UUI instrument
  3. Applicarions of PET-UUI in oncology research
  4. Applications of PET-UUI in cardiology research

 

 

About the speaker

Bertrand TavitianBertrand Tavitian, MD
Professor of Radiology and Medical Imaging

Present position:

  • Professor of Radiology and Medical Imaging (Professeur des Universités – Praticien des Hôpitaux) at the Faculty of Medicine of Paris Descartes;
  • Director, Imaging research Laboratory of Paris Cardiovascular Research Center (Inserm U970)
  • Director of the Network for in vivo imaging of University Paris Descartes

 

Education:

  • Ecole Normale Supérieure, Paris 1977-1982.
  • Professor (“Agrégation”) of Biochemistry & Biological Engineering, 1982.
  • Doctor in Medicine, Faculty of Medicine of University Paris Descartes, 1985.
  • Accreditation for Research Supervision (“Habilitation à diriger les Recherches”), University Paris-Sud, 1999.

 

Previous positions:

  • Director of the Laboratory for Experimental Molecular Imaging and head of Inserm U1023 « In vivo imaging of gene expression» (Inserm – CEA), Orsay, France, 2001-2012
  • Director of the platform for innovative imaging technologies (PET, SPECT, CT and optical imaging) in small-animal imaging research, Institute for Biomedical Imaging, Orsay, France, 2007-2012.

 

Research summary:

  • In vivo molecular imaging of gene expression for physiology and pathophysiology

 

Present research interests:

  • Imaging the relationship between metabolism and vascularization in tumors, heart and brain. Development of hybrid imaging instruments.
  • Tools and software for imaging research management and data mining
  • Translation of preclinical imaging research into clinical applications.
  • Long-time interest in the use of nucleic acids (antisense, aptamers, interfering RNAs, ribozymes,etc) for imaging, both as biotechnological tools for imaging probe development and as pharmacologically active compounds.

 

Scientific production:

  • 114 peer-reviewed publications (Pubmed), 12 patents

 

Student supervision:

  • PhDs 1994-present, n=17. Two (2005, 2016) received the Prize of the Paris Chancery for best PhD.
  • Post-doctoral students, n = 19 including 14 postdoctoral fellows from abroad France.

 

Coordination of Research programs

  • Coordinator, FP6 program OLIM (Oligonucleotides for Imaging), 1997-2000.
  • Coordinator, FP7 Network of excellence EMIL (European Laboratories for Molecular Imaging of Cancer), 2004-2009
  • Founder and first President of the European Society for Molecular Imaging (ESMI), 2005-2008
  • PI in five European FP6 and FP7 projects, PI and co-PI in over 20 National research programs,

 

Awards

  • Laureate of the Faculty of Medicine, Paris 1985
  • American Nuclear Society, Special Award for Nuclear Techniques in Medical Diagnosis and Treatment, 1999
  • Major Achievement in European Research, 1999
  • Eurocancer Great Scientific Prize 2005
  • European Society for Molecular Imaging Award 2007


 ESHI_Webinars_2017

PAST WEBINARS 2017

 

 

Webinar 1 - HYBRID IMAGING: BASICS

Date: February 22, 2017
Time: 17:00 (CET)
Speaker: Thomas Beyer, PhD (Vienna, Austria)

Description
The past decade has been a decade of hybrid imaging. Hybrid imaging comprises hardware combinations of complementary anatomical and molecular imaging methods. These include SPECT/CT, PET/CT and PET/MR, with other options being discussed and explored.

This webinar is on the basics of hybrid clinical imaging today. The tutor is Thomas Beyer, PhD, a co-developer of PET/CT. He will briefly explain the origins of hybrid imaging (SPECT/CT, PET/CT and PET/MR) before highlighting the basic methodologies associated with these imaging technologies. The webinar will include an update on applications and challenges before ending with an outlook. The key take home message is “Moving machineries closer together, requires to do the same with people and expertises”.

Learning Objectives:

  1. To review the origins of SPECT/CT, PET/CT and PET/MR imaging systems.
  2. To understand the basic principles and general clinical applications.
  3. To speculate on trends in dual-modality PET- and SPECT-based imaging technology.

About the Speaker

Beyer_201607Thomas Beyer holds a PhD in Physics and is co-developer of the first combined PET/CT system worldwide. He has a background in research and project management in academia and imaging industry.

Thomas graduated in Physics at the Leipzig University (Germany) and got his PhD in Medical Physics from Surrey University (UK). During his US-based studies he became involved in the development and clinical testing of the first PET/CT prototype (1992-2000) before joining Siemens/CTI PET Systems as an International PET/CT specialist.

In 2002 he became a Research Associate in Nuclear Medicine and Radiology and PET/CT project manager at Essen University Hospital (Germany). In 2006 he became Teaching Professor (Priv-Doz) for Experimental Nuclear Medicine at Essen, and joined timaq medical imaging Inc, a Zurich-based Imaging CRO. In 2007 he moved to Philips Medical Systems as International Manager Clinical Science Nuclear Medicine. In 2008 he set up a Zurich-based consulting company for expert advise in cross-modality imaging and applications. He is appointed full professor of Physics of Medical Imaging at the Medical University of Vienna from March 2013.

Thomas is a member of various national and international Medicine organizations, a founding member of the European Association of Nuclear Medicine (EANM) Physics Committee and past Head of the New Technology working group at the Association of Imaging Producers and Equipment Suppliers (AIPES). He is a co-founder of the European Society of Hybrid Imaging and a Board M

Webinar 2 - CLINICAL HYBRID IMAGING

Date: March 29, 2017
Time: 17:00 (CET)
Speaker: Osman Ratib MD, PhD (Geneva/CH)

 

Description:

Hybrid imaging brings more to clinical practice and patient management than simple fusion of images from different imaging modalities. Since the introduction of PET-CT in clinical practice and later the extension of hybrid modalities to SPECT-CT and PET-MRI, specific applications of these modalities emerged, addressing clinical issues beyond the simple added value of better localization and diagnostic confidence of the combination of metabolic anomalies and their specific localisation in organs and tissues.

This webinar will review theses well established applications of hybrid imaging in specific clinical domains such as on oncology for breast, head and neck and prostate imaging, in neurodegenerative diseases, in assessment of musculoskeletal diseases and in cardiovascular imaging.

 

Learning objectives:

  1. To review the clinical applications of the different hybrid modalities
  2. To learn about the current clinical guidelines and best practices of use of hybrid imaging in clinical practice
  3. To foresee current and future developments in molecular imaging techniques and their potential impact on patient management

 

About the Speaker

Pic_Osman RatibProfessor Osman Ratib is dual board certified in cardiology and Nuclear Medicine and carries a PhD in Biomedical Physics in digital imaging. In July 1998 he was appointed as Professor and Vice Chairman of the Department of Radiology at University of California Los Angeles (UCLA).

He was responsible for coordinating the deployment of an enterprise-wide strategy and infrastructure for image management and communication. In July 2005 he returned to Geneva to take the position chair of the Department of Medical Imaging and Information Sciences and head of the Nuclear Medicine division. He pioneered several innovative projects in hybrid molecular imaging PET-CT and SPECT-CT and the first whole-body PET-MRI unit in Europe.

He is founder and president of the OsiriX foundation, a non-profit organization for the promotion of Open-Source software in medicine. Founder and director of the Translational Molecular Imaging Institute in Geneva, created under the joint leadership of to the University of Geneva and Technical university EPFL in Lausanne.

Webinar 3 - PET/CT IN LYMPHOMA

Date: April 26, 2017
Time: 17:00 (CEST)
Speaker: Prof. Gerald Antoch, MD (Düsseldorf/DE)

 

Description:

This webinar will be held as a hands-on course to guide the radiologist and nuclear medicine physician on how to use PET/CT in patients with lymphoma. This course will summarize typical findings on CT and FDG-PET, which complement one another at the time of diagnosis and tumor staging.

While morphology is important in diagnosis,  differential diagnosis, and staging, therapy response assessment is mainly based on FDG-PET. But, on which criteria do you base therapy response assessment with PET? Should you perform interim-PET or PET at the end-of-treamtent? And, how does immunotherapy affect your PET results?

Watch the webinar, and you will know!

 

Learning objectives:

  1. To learn about typical findings of FDG-PET/CT in lymphoma.
  2. To review international recommendations for staging and therapy response assessment in lymphoma.
  3. To communicate criteria applied for therapy response assessment with PET/CT.

 

About the Speaker

Pic_Gerald AntochGerald Antoch is professor of radiology and chairman of the department of diagnostic and interventional radiology at Düsseldorf University Hospital.

After completing his medical training, Dr. Antoch began working in general surgery before starting his training in diagnostic and interventional radiology at Essen University Hospital. He became a board certified radiologist in 2004. From 2004 to 2008, he worked as a consultant radiologist and became vice chairman of the department of radiology at Essen University Hospital in 2008. In 2010 he was appointed chairman of the department of diagnostic and interventional radiology at Düsseldorf University Hospital.

Prof. Antoch’s scientific research focuses on clinical hybrid imaging. He has published 209 original scientific articles and reviews, as well as 20 book chapters. He has received widespread recognition for his work with a number of awards. In 2003, he received the Alavi-Mandell Award from the Society of Nuclear Medicine, United States, and that same year he won Aunt Minnie’s Best Scientific Paper Award, which he won again in 2004. In 2005 he was awarded the Lodwick Award at Harvard Medical School followed by awards from the Bavarian Association of Nuclear Medicine and the German Cancer Research Center in the same year. In 2007 the German Radiological Society presented Prof. Antoch with the Wilhelm Conrad Röntgen Award.

 

Webinar 4 - HYBRID IMAGING IN HEAD AND NECK CANCER

Date: May 31, 2017
Time: 17:00 (CEST)
Speaker: Dr. Sergios Gatidis (Tübingen/DE)

 

Description:

This webinar will give an overview over the use of hybrid imaging in the diagnostic work-up of patients with head and neck cancer. Specific technical challenges and pitfalls of head and neck imaging and available solutions will be summarized. Current indications for the use of PET/CT and PET/MRI will be presented in the context of international guidelines.

In addition, comparative strengths and limitations of PET/CT and PET/MRI will be discussed in a clinical context and with respect to research applications. Potential future applications including the use of specific PET tracers will be presented.

 

Learning objectives:

  1. To learn about technical challenges and possible solutions in head and neck imaging.
  2. To know about international recommendations for the use of hybrid imaging in head and neck cancer.
  3. To assess strengths and limitations of PET/CT and PET/MRI for imaging of head and neck cancer.

 

About the speaker:

Picture_Sergios_GatidisSergios Gatidis is Radiologist at the Department of Radiology of the University Hospital in Tübingen/Germany.

He studied Medicine and Mathematics at the Eberhard-Karl-Universität Tübingen.

Currently he is responsible for the multidisciplinary PET/MRI research group in Tübingen. S. Gatidis’ focus of research lies in clinical hybrid imaging studies and the development of techniques for the analysis of multiparametric imaging data from PET/CT, MRI and PET/MRI.

Webinar 5 - PET/CT IN LUNG CANCER
Date: June 28, 2017
Time: 17:00 (CEST)
Speaker: Prof. Dr. Dr. Katrine Riklund (Umeå/SE)

 

Description:

The lecture will be an intoduction to the use of FDG-PET/CT in staging of lung cancer. The TNM classification system will be briefly covered and how to use FDG for metabolic staging will be discussed. Some typical FDG-PET/CT lung cancer cases will also be demonstrated.

 

Learning objectives:

  • To learn about TNM classification of lung cancer
  • to understand metabolic staging of lung cancer with FDG-PET/CT
  • to learn about interpretation of examination with FDG-PET/CT in lung cancer

 

About the speaker

Katrine Riklund, graduated at Umeå university in 1988, licensed in radiology in 1994 and in nuclear medicine in 1997. She

defended her PhD thesis about radioimmunoscintigraphy and radioimmunitherapy, in 1992, and received a position as senior lecturer in 1993.

In 2002 she was appointed as full clinical professor in diagnostic radiology at Umeå University and she still holds that position. During 2000-2002 Dr. Riklund was the head of the clinical department of Radiology at Umeå university hospital and is thereafter responsible for the department of nuclear medicine. She was deputy dean of the medical faculty 2008-2011 and is now the director of the medical school. 

Dr. Riklund started her work in science in translational research between immunology and nuclear medicine by developing and evaluation of monoclonal antibodies in the diagnosis and treatment of gynecological cancers.Thereafter hybrid imaging took her interest and imaging research in cognition, neurodegeneration and movement disorders was added. Oncologic imaging of prostate and colorectal cancer is her third area of interest.

The linker between the different areas in her research is hybrid imaging, SPECT/CT, PET/CT and PET/MR. The research also includes a focus on dopamine in imaging, both pre- and postsynaptic.

She has several commitments in radiology societies and is the past president of both the Swedish society of radiology and the Swedish society of nuclear medicine. She is the Chair of the Board of Center for medical image science and visualisation, University of Linköping, Sweden. At moment, she is immediate Past President of the European Society of Radiology and the first President of the European Society of Hybrid Medical Imaging.

Webinar 6 - COMBINED PET/MRI: METHODS AND APPLICATIONS

Date: September 18, 2017
Time: 17:00 (CEST)
Speaker: Thomas Beyer, PhD (Vienna/AT)

Description
Combined PET/MRI has been around for close to a decade now, generating a lot of hype and some clinical traction. This webinar aims at 3 main objectives: First, we will review briefly the key methodological aspects of PET/MRI, so as to understand its diagnostic potential for clinical work and research applications. Second, we will review briefly the clinical status of whole-body PET/MRI. And third, we will highlight a few key applications in research.

The main conclusion from this webinar will be “PET/MRI is synonymous with global warming” along the lines of the recent white paper on the 6th Tübingen PET/MR workshop (to appear in ‘Molecular Imaging and Biology’ (MIB) in 12/17).

Learning Objectives: 

  1. To review the key methodological aspects of combined PET/MRI.
  2. To highlight the main clinical applications.
  3. To promote key applications for PET/MRI from a research angle.
  4. To speculate on the future of PET/MRI.

 

About the Speaker

Beyer_201607Thomas Beyer holds a PhD in Physics and is co-developer of the first combined PET/CT system worldwide. He has a background in research and project management in academia and imaging industry.

Thomas graduated in Physics at the Leipzig University (Germany) and got his PhD in Medical Physics from Surrey University (UK). During his US-based studies he became involved in the development and clinical testing of the first PET/CT prototype (1992-2000) before joining Siemens/CTI PET Systems as an International PET/CT specialist.

In 2002 he became a Research Associate in Nuclear Medicine and Radiology and PET/CT project manager at Essen University Hospital (Germany). In 2006 he became Teaching Professor (Priv-Doz) for Experimental Nuclear Medicine at Essen, and joined timaq medical imaging Inc, a Zurich-based Imaging CRO. In 2007 he moved to Philips Medical Systems as International Manager Clinical Science Nuclear Medicine. In 2008 he set up a Zurich-based consulting company for expert advise in cross-modality imaging and applications. He is appointed full professor of Physics of Medical Imaging at the Medical University of Vienna from March 2013.

Thomas is a member of various national and international Medicine organizations, a founding member of the European Association of Nuclear Medicine (EANM) Physics Committee and past Head of the New Technology working group at the Association of Imaging Producers and Equipment Suppliers (AIPES). He is a co-founder of the European Society of Hybrid Imaging and a past Head of the New Technology working group at the Association of Imaging Producers and Equipment Suppliers (AIPES).

Webinar 7 - CARDIAC PET/MR

Date: October 25, 2017
Time: 17:00 (CEST)
Speaker: Prof. Dr. Mathias Gutberlet (Leipzig/DE)

Description:

Cardiac MRI and Cardiac PET are both important imaging modalities for clinical decision making as well as for research in cardiovascular disease. Both modalities have developed a lot during the recent two decades. Therefore, a combination of the best of both modalities seems to be quite promising. The principles of different PET/MR systems with its advantages and disadvantages as well as potential indications for PET/MR in the cardiovascular system on the basis of the position statement:

“Hybrid cardiac imaging using PET/MRI: A joint position statement by the European Society of Cardiac Radiology (ESCR) and the European Association of Nuclear Medicine (EANM)” will be described during the Webinar.

Learning Objectives:
  • To get knowledge of the technical principles of a PET/MR system
  • To learn more about the technical challenges to build a PET/MR system
  • To know the advantages and disadvantages of a combined PET/MR system
  • To learn more about the potential indications for PET/MR in the cardiovascular system

 

About the speaker:

Pic_Matthias GutberletProf. Dr. Matthias Gutberlet is Specialist in Radiology and Nuclear Medicine and currently is Head of the Department for Diagnostic and Interventional Radiology at the University Leipzig. He is also Past-President of the European Society of Cardiac Radiology (ESCR).

Clinical Work:
Beside diagnostic imaging and treatment of diseases of the cardiovascular system our department provides the radiological service for the Park-Klinikum Leipzig with a main focus on the muscoloskeletal system, gastroenterology and pulmology. We are part of a “Onkozert” certified “Darm- and Pankreaszentrum” since 2008. My multimodality experience in oncology startet at the Charité, Campus Virchow, including PET/CT reading and was continued as a reviewer for Parexcel-Berlin in 2005/2006. At the University Leipzig I am still involved in clinical and research Activities at the PET/MR-system.

Research:
I was mainly involved in research projects dealing with Doppler-ultrasound, contrast agents, MDCT and MRI of the cardiovascular system, using the techniques of dynamic CTA, Dual Energy, iterative reconstruction, coronary CTA, MR-angiography, MR-volumetry, MR flow-measurements and MR-perfusion in humans and animal models. I am one of the project leaders of the German Competence Network for Congenital Heart Disease since 2003.

Recent studies of our group were dealing with dose reduction in CT, imaging and post-processing before and after TAVI and EVAR, MR viability assessment in comparison to SPECT, PET, MRI at 3.0T and studies on the assessment of inflammation by MRI. Furthermore, we have gathered the first experiences in PET/MR and interventional MRI.

Webinar 8 - PET/MR IN PAEDIATRIC ONCOLOGY

Date: November 22, 2017
Time: 17:00 (CET)
Speaker: Prof. Dr. Jürgen Schäfer (Tübingen/DE)

Description:

In theory, the combination of PET and MRI might be the best modality for paediatric cancer imaging. The rationales for this hypothesis are: (a) the significantly lower radiation exposure even in comparison to low-dose PET/CT, (b) the higher diagnostic accuracy as compared to PET/CT even when using diagnostic contrast-enhanced CT, (c) the unique possibility to combine distinct MR-inherent contrasts (e.g. DWI) with specific PET-tracers for the evaluation of novel targeted therapies, and (d) the opportunity to stage local and systemic tumour burden within a single examination.

On the other hand, many circumstances are challenging the extensive use of PET/MRI in children. In general, the availability of PET/MRI systems is still low. Thus, only a few sites in Europe have experience particularly children. Therefore, the scientific evidence is restricted.  Moreover, whole-body-MRI is not a broadly adopted method for the combined assessment of local disease extent and whole-body staging, potentially replacing other whole-body modalities like the bone scan.  In this context, especially the detection of pulmonary metastases is biased also against PET/MRI.  Finally harmonized sequence protocols and specific recommendations for tracer dosage are not available for PET/MRI. However, that will be launched in the next future.

Learning Objectives:

  • To understand the principles of simultaneous PET/MR in children
  • To have a knowledge of advantages and limitations of PET/MR in daily practice
  • To list indications for PET/MR in children with cancer
Webinar 9 - PET/CT ARTIFACTS AND SOLUTIONS

Date: December 20, 2017
Time: 17:00 (CET)
Speaker: Thomas Beyer, PhD (Vienna, Austria)

 

Description

Image artifacts may impact patient diagnosis. This webinar will highlight common image distortions in hybrid PET/CT and PET/MR imaging and – together with the audience – probe the causes of these artifacts as well as provide work-around solutions. This will be an interactive course where participants are invited to partake in MC question tests.

 

Learning objectives:
1. To appreciate the origin and appearance of common image distortions in clinical PET/CT and PET/MRI
2. To vote on the causes of the artifacts (interactive case studies)
3. To understand workaround solutions to reduce the frequency / magnitude of these image distortions”
About the Speaker

Beyer_201607Thomas Beyer holds a PhD in Physics and is co-developer of the first combined PET/CT system worldwide. He has a background in research and project management in academia and imaging industry.

Thomas graduated in Physics at the Leipzig University (Germany) and got his PhD in Medical Physics from Surrey University (UK). During his US-based studies he became involved in the development and clinical testing of the first PET/CT prototype (1992-2000) before joining Siemens/CTI PET Systems as an International PET/CT specialist.

In 2002 he became a Research Associate in Nuclear Medicine and Radiology and PET/CT project manager at Essen University Hospital (Germany). In 2006 he became Teaching Professor (Priv-Doz) for Experimental Nuclear Medicine at Essen, and joined timaq medical imaging Inc, a Zurich-based Imaging CRO. In 2007 he moved to Philips Medical Systems as International Manager Clinical Science Nuclear Medicine. In 2008 he set up a Zurich-based consulting company for expert advise in cross-modality imaging and applications. He is appointed full professor of Physics of Medical Imaging at the Medical University of Vienna from March 2013.

Thomas is a member of various national and international Medicine organizations, a founding member of the European Association of Nuclear Medicine (EANM) Physics Committee and past Head of the New Technology working group at the Association of Imaging Producers and Equipment Suppliers (AIPES). He is a co-founder of the European Society of Hybrid Imaging and a past Head of the New Technology working group at the Association of Imaging Producers and Equipment Suppliers (AIPES).